Evaluation of the effects of restraint and footshock stress on small intestinal motility by an improved method using a radionuclide, Cr-51, in the rat

Tsukada, F Sugawara, M Kohno, H Ohkubo, Y

F. Tsukada et al., Evaluation of the effects of restraint and footshock stress on small intestinal motility by an improved method using a radionuclide, Cr-51, in the rat, BIOL PHAR B, 24(5), 2001, pp. 488-490

25

INGLESE

Article

Pharmacology & Toxicology

BIOLOGICAL & PHARMACEUTICAL BULLETIN

0918-6158 → ACNP

24

5

2001

488 - 490

ISI

0918-6158(200105)24:5<488:EOTEOR>2.0.ZU;2-8

The effect of two different stress stimuli, restraint stress and footshock stress, on small intestinal motility was evaluated by a more reliable metho d with improvement of the previous method using a radionuclide, Cr-51. The small intestinal transit was significantly inhibited by restraint stress, b ut not by footshock stress, although plasma corticosterone levels were sign ificantly elevated to the same extent by restraint stress and footshock str ess, These results suggest that restraint stress and footshock stress stimu li influence small intestinal motility via different mechanisms, but the re ason for the difference is unclear, This experimental system using Cr-51 se ems to be useful for the elucidation of mechanisms for restraint stress-ind uced dysfunction of small intestinal motility because of its excellent quan titative evaluation of small intestinal transit.