Evaluation of the effects of restraint and footshock stress on small intestinal motility by an improved method using a radionuclide, Cr-51, in the rat

Citation
F. Tsukada et al., Evaluation of the effects of restraint and footshock stress on small intestinal motility by an improved method using a radionuclide, Cr-51, in the rat, BIOL PHAR B, 24(5), 2001, pp. 488-490
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
5
Year of publication
2001
Pages
488 - 490
Database
ISI
SICI code
0918-6158(200105)24:5<488:EOTEOR>2.0.ZU;2-8
Abstract
The effect of two different stress stimuli, restraint stress and footshock stress, on small intestinal motility was evaluated by a more reliable metho d with improvement of the previous method using a radionuclide, Cr-51. The small intestinal transit was significantly inhibited by restraint stress, b ut not by footshock stress, although plasma corticosterone levels were sign ificantly elevated to the same extent by restraint stress and footshock str ess, These results suggest that restraint stress and footshock stress stimu li influence small intestinal motility via different mechanisms, but the re ason for the difference is unclear, This experimental system using Cr-51 se ems to be useful for the elucidation of mechanisms for restraint stress-ind uced dysfunction of small intestinal motility because of its excellent quan titative evaluation of small intestinal transit.