K. Takeuchi et al., Effects of dermatan and dextran sulfates on arginine amidase activity released from isolated rabbit arteries, BIOL PHAR B, 24(5), 2001, pp. 465-469
We examined the levels of arginine amidase secreted from isolated rabbit ar
teries treated with dermatan and dextran sulfates, and the relation between
the secretion of arginine amidase activity and the concentration of dermat
an sulfate added to these arteries, The results showed that while dextran s
ulfate tended to accelerate the release of arginine amidase activity from t
he isolated rabbit ear artery, the induction was not significant. There was
a significant increase in tile level of arginine amidase released flam the
lower portion of isolated rabbit aorta (p < 0.05), but no significant chan
ge in the upper portion of the aorta. In contrast, the addition of dermatan
sulfate significantly increased the level of arginine amidase activity rel
eased from the isolated rabbit ear artery and the upper and low er portions
of the aorta (p < 0.05).
Linear dose-response relationships were observed between the level of argin
ine amidase activity released front the Isolated rabbit ear artery and aort
a and the concentration of dermatan sulfate added.