Effects of dermatan and dextran sulfates on arginine amidase activity released from isolated rabbit arteries

Citation
K. Takeuchi et al., Effects of dermatan and dextran sulfates on arginine amidase activity released from isolated rabbit arteries, BIOL PHAR B, 24(5), 2001, pp. 465-469
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
5
Year of publication
2001
Pages
465 - 469
Database
ISI
SICI code
0918-6158(200105)24:5<465:EODADS>2.0.ZU;2-G
Abstract
We examined the levels of arginine amidase secreted from isolated rabbit ar teries treated with dermatan and dextran sulfates, and the relation between the secretion of arginine amidase activity and the concentration of dermat an sulfate added to these arteries, The results showed that while dextran s ulfate tended to accelerate the release of arginine amidase activity from t he isolated rabbit ear artery, the induction was not significant. There was a significant increase in tile level of arginine amidase released flam the lower portion of isolated rabbit aorta (p < 0.05), but no significant chan ge in the upper portion of the aorta. In contrast, the addition of dermatan sulfate significantly increased the level of arginine amidase activity rel eased from the isolated rabbit ear artery and the upper and low er portions of the aorta (p < 0.05). Linear dose-response relationships were observed between the level of argin ine amidase activity released front the Isolated rabbit ear artery and aort a and the concentration of dermatan sulfate added.