Background: Non-invasive methods to detect the presence of H. pylori infect
ion continue to be refined.
Aim: To evaluate a new 20-min immunochromatography method (RAPIRUN H. pylor
i Antibody) for the presence of anti-H. pylori IgG in urine.
Methods: We used the C-13-urea breath test to establish H. pylori status. W
e evaluated the urine test among 104 subjects including 43 with H. pylori i
nfection confirmed by repeatedly positive urea breath tests and 61 H. pylor
i-negative subjects with repeatedly negative urea breath tests. Forty-one o
f the 43 subjects with H. pylori infection had a positive rapid urine test
with two false negative tests. There were two false positive tests among th
e 61 with repeatedly negative urea breath tests. The sensitivity, specifici
ty, positive and negative predictive values for the rapid urine test were 9
5.3%, 96.7%. 95.3%, and 96.7%, respectively. The kit was easy to use and re
quired no special equipment.
Conclusions: The rapid immunochromatography method for determination of ant
i-H. pylori IgG proved to be reliable with excellent sensitivity and specif
icity and is likely to be useful for both clinical and epidemiological stud