Colonic motility in chronic ulcerative proctosigmoiditis and the effects of nicotine an colonic motility in patients and healthy subjects

Citation
B. Coulie et al., Colonic motility in chronic ulcerative proctosigmoiditis and the effects of nicotine an colonic motility in patients and healthy subjects, ALIM PHARM, 15(5), 2001, pp. 653-663
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
5
Year of publication
2001
Pages
653 - 663
Database
ISI
SICI code
0269-2813(200105)15:5<653:CMICUP>2.0.ZU;2-8
Abstract
Background: Nicotine decreases diarrhoea and pain in ulcerative colitis wit hout reducing inflammation. Aims: (i) To evaluate the effect of ulcerative proctosigmoiditis on motor f unctions of an uninflamed segment of descending colon: and (ii) to assess n icotine's effects on colonic motor functions in patients and healthy subjec ts. Methods: In healthy subjects (n = 30) and patients with ulcerative colitis (13; 11 active, two quiescent colitis), we studied the effects of intraveno us nicotine on colonic transit of solid residue by scintigraphy (healthy su bjects) and on colonic motility in healthy subjects and 11 patients. Results: In ulcerative colitis, fasting colonic motility was increased, whe reas motor response to a meal was significantly reduced; compliance was unc hanged, in healthy subjects, high-dose nicotine induced transient high ampl itude propagated contractions and relaxation of the descending colon follow ed by decreased phasic contractions. This dose also accelerated colonic tra nsit. Low-dose nicotine (mimicking a transdermal nicotine patch) reduced co lonic compliance in healthy subjects, but did not affect motor function in ulcerative colitis. Conclusions: Ulcerative proctosigmoiditis increases fasting colonic motilit y and reduces tone response to a meal in the descending colon without affec ting colonic compliance, suggesting changes in physiological responses but not intrinsic wall properties. Nicotine has dose-dependent effects on colon ic motor activity in healthy subjects.