Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia

Citation
O. Shirakawa et al., Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia, PROG NEUR-P, 25(4), 2001, pp. 867-877
Citations number
35
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Neurosciences & Behavoir
Journal title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN journal
0278-5846 → ACNP
Volume
25
Issue
4
Year of publication
2001
Pages
867 - 877
Database
ISI
SICI code
0278-5846(200105)25:4<867:ANAITT>2.0.ZU;2-U
Abstract
1. Neuroanatomical asymmetries are known to be present in the human brain, and loss of reversal of these asymmetries, particularly through changes in the left temporal lobe, have been found in the brains of patients with schi zophrenia. 2. In addition to disturbed neuroanatomical asymmetries, disturbed neuroche mical asymmetries have also been reported in the brains of patients with sc hizophrenia. However, in the temporal lobe, the laterality of most of these neurochemical changes has not been specifically evaluated. Few neurochemic al studies have addressed left-right differences in the superior temporal g yrus (STG). 3. A deteriorated serotonin2A receptor-G protein q alpha (Gq alpha)-phospho inositide-specific phospholipase C beta1(PLC beta1) cascade has been found in the left, but not right, STG of patients with schizophrenia. 4. Not only neuroanatomical but also neurochemical evidence supports the lo ss or reversal of normal asymmetry of the temporal lobe in schizophrenia, w hich might be due to a disruption of the neurodevelopmental processes invol ved in hemispheric lateralization.