Treatment of sepsis in cardiac surgery: role of immunoglobulins

Citation
A. Sablotzki et al., Treatment of sepsis in cardiac surgery: role of immunoglobulins, PERFUSION-U, 16(2), 2001, pp. 113-120
Citations number
84
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
PERFUSION-UK
ISSN journal
0267-6591 → ACNP
Volume
16
Issue
2
Year of publication
2001
Pages
113 - 120
Database
ISI
SICI code
0267-6591(200103)16:2<113:TOSICS>2.0.ZU;2-3
Abstract
Cardiopulmonary bypass (CPB) is associated with an injury that may cause pa thophysiological changes such as systemic inflammatory response syndrome, m ultiple organ dysfunction syndrome, and mediator-induced multiorgan failure . Systemic endotoxinaemia, release of proinflammatory cytokines. and intera ctions between neutrophils and endothelium have been reported to correlate with a high incidence of organ dysfunction. infection and sepsis following cardiac surgery. This review discusses the dysregulation of the immune resp onse as a major reason for the higher susceptibility to infections followin g cardiac surgery, various treatment strategies to reduce CPB-induced infla mmation, and especially the prophylactic use of immunoglobulins in cardiac surgery.