Predictors and underlying causes of medically intractable localization-related epilepsy in childhood

Citation
Y. Ohtsuka et al., Predictors and underlying causes of medically intractable localization-related epilepsy in childhood, PED NEUROL, 24(3), 2001, pp. 209-213
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
PEDIATRIC NEUROLOGY
ISSN journal
0887-8994 → ACNP
Volume
24
Issue
3
Year of publication
2001
Pages
209 - 213
Database
ISI
SICI code
0887-8994(200103)24:3<209:PAUCOM>2.0.ZU;2-W
Abstract
The goal of this study is to clarify the prognostic factors in childhood lo calization-related epilepsy in a tertiary medical center. Children (n = 113 ) with symptomatic and cryptogenic localization-related epilepsy were divid ed into groups of intractable patients (average seizure frequency: one or m ore per month during the 6 months before the last follow-up; n = 40) and we ll-controlled patients (no seizures for at least 1 year before the last fol low-up; n = 73), Clinical and electroencephalogram (EEG) factors were exami ned to elucidate prognostic factors. The subtypes of epilepsies and causes were also investigated. Univariate analyses indicated that the following fa ctors were correlated with seizure outcome: (1) seizure type at the first v isit; (2) seizure frequency; (3) underlying cause; (4) age at onset of epil epsy; (5) status epilepticus occurring as the first seizure and before the first visit; and (6) diffuse epileptic discharges on first visit interictal EEGs, Multivariate analyses revealed that seizure type at the first visit, seizure frequency, status epilepticus before the first visit, and underlyi ng causes were significant independent predictive factors. The rate of intr actable patients was highest in multilobar epilepsy, followed by frontal-lo be epilepsy. Regarding etiologies, the intractable group contained nine pat ients with encephalitis of unknown origin and three each with localized cor tical malformation and mesial temporal sclerosis, (C) 2001 by Elsevier Scie nce Inc. All rights reserved.