Correlation between TGF-beta 1 and p21 (WAF1/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas

Citation
K. Hashimoto et al., Correlation between TGF-beta 1 and p21 (WAF1/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas, PANCREAS, 22(4), 2001, pp. 341-347
Citations number
53
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
PANCREAS
ISSN journal
0885-3177 → ACNP
Volume
22
Issue
4
Year of publication
2001
Pages
341 - 347
Database
ISI
SICI code
0885-3177(200105)22:4<341:CBT1AP>2.0.ZU;2-T
Abstract
Transforming growth factor-beta1 (TGF-beta1) inhibits the growth of a varie ty of epithelial cells; however, in many types of tumors it loses its inhib itory effect. p21(WAF1/CIP1), one of the cyclin-dependent kinase (Cdk) inhi bitors induced by TGF-beta1, is considered a downstream effector of the gro wth-inhibitory function of TGF-beta1. We assessed the clinicopathologic sig nificance of TGF-beta1 and p21 expression in resectable invasive ductal car cinoma (IDC) of the pancreas. Immunohistochemical examination of the expres sion of TGF-beta1 and p21 in 62 patients revealed positive expression of TG F-beta1 in 28 (45%) and of p21 in 25 (40%) of the 62 patients, and a signif icant correlation between the two expressions. The survival curve of patien ts with TGF-beta1(+) tumors was significantly higher than that of patients with TGF-beta1(-) tumors; p21(+) patients showed a higher survival curve th an did p21(-) patients, but the difference was not statistically significan t. Simultaneous analysis of TGF-beta1 and p21 expression showed that the pa tients with TGF-beta1(+)/p21(+) tumors had a significantly better prognosis than the others. Multivariate analysis showed that TGF-beta1 was a signifi cantly low risk factor for death due to IDC. The concurrent evaluation of T GF-beta1 and p21 expression would be an effective tool in the prediction of the prognosis of patients with pancreatic cancer.