Systemic fusariosis after a preparative regimen including thiotepa, VP-16 and busulfan used for blood stem cell transplantation in Hodgkin's disease

Miyazaki, M Miyakoshi, S Kami, M Mori, M Kishi, Y Inagawa, H Machida, U Matsumura, T Kawagoe, S Ueyama, JI Morinaga, SI Matsushita, H Muto, Y

M. Miyazaki et al., Systemic fusariosis after a preparative regimen including thiotepa, VP-16 and busulfan used for blood stem cell transplantation in Hodgkin's disease, LEUK LYMPH, 40(3-4), 2001, pp. 441-444

10

INGLESE

Article

Hematology,"Onconogenesis & Cancer Research

LEUKEMIA & LYMPHOMA

1042-8194 → ACNP

40

3-4

2001

441 - 444

ISI

1042-8194(200101)40:3-4<441:SFAAPR>2.0.ZU;2-Y

Fusarium infection is rare but important infection after bone marrow transp lantation (BMT). A 27-year-old man developed systemic fusarial infection fo llowing severe skin damage prob abl; caused by high-doss thiotepa administr ation. Systemic fusariosis rapidly progressed to a variety of organs despit e antifungal treatment, and he finally died of this infection on day 75. Co nsidering that this organism usually invades via damaged skin and that the penile lesion was the first manifestation of systemic fusariosis in this pa tient. careful examination of the skin might be helpful for early diagnosis of fusarial infection. His clinical course provided us with an important c lue for diagnosis of fusarial infection.