Systemic fusariosis after a preparative regimen including thiotepa, VP-16 and busulfan used for blood stem cell transplantation in Hodgkin's disease

Citation
M. Miyazaki et al., Systemic fusariosis after a preparative regimen including thiotepa, VP-16 and busulfan used for blood stem cell transplantation in Hodgkin's disease, LEUK LYMPH, 40(3-4), 2001, pp. 441-444
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
40
Issue
3-4
Year of publication
2001
Pages
441 - 444
Database
ISI
SICI code
1042-8194(200101)40:3-4<441:SFAAPR>2.0.ZU;2-Y
Abstract
Fusarium infection is rare but important infection after bone marrow transp lantation (BMT). A 27-year-old man developed systemic fusarial infection fo llowing severe skin damage prob abl; caused by high-doss thiotepa administr ation. Systemic fusariosis rapidly progressed to a variety of organs despit e antifungal treatment, and he finally died of this infection on day 75. Co nsidering that this organism usually invades via damaged skin and that the penile lesion was the first manifestation of systemic fusariosis in this pa tient. careful examination of the skin might be helpful for early diagnosis of fusarial infection. His clinical course provided us with an important c lue for diagnosis of fusarial infection.