Leukemia cutis in an elderly patient treated with low dose cytosine arabinoside and etoposide

Citation
T. Bohgaki et al., Leukemia cutis in an elderly patient treated with low dose cytosine arabinoside and etoposide, LEUK LYMPH, 40(3-4), 2001, pp. 433-436
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
40
Issue
3-4
Year of publication
2001
Pages
433 - 436
Database
ISI
SICI code
1042-8194(200101)40:3-4<433:LCIAEP>2.0.ZU;2-N
Abstract
A 78-year-old man presented with a generalized erythematous papular rash. S uch skin lesions were not painful, tender or pruritic. and spread over the truncus. He was admitted to our hospital for examination of the skin lesion s. Laboratory tests indicated microcytic hypochromatic anemia and thrombocy topenia, although gave a normal leukocyte count with normal differentiation . His bone marrow showed hypercellularity. with 43% peroxidase positive bla sts that displayed positive immunophenotypes for CD4, CD13, CD33, CD41a. KP -1 (CD68), and HLA-DR. His skin specimen revealed infiltration in the dermi s and subcutaneous fat tissue by leukemic cells that were positive for the leukocyte common antigen (LCA, CD45). CD15, CD33. CD68. and HLA-DR. He was diagnosed as having M4 subtype of acute myelogeneous leukemia (AML) with le ukemia cutis. After three courses of low dose cytosine arabinoside (LDAC), combined with low dose etoposide, he achieved complete remission (CR). He r emained well, with no evidence of relapse nine months later. LDAC should be considered as initial treatment for such cases of leukemia cutis with poor general condition.