Lack of correlation between clinical characteristics and serum soluble Fasligand levels in patients with multiple myeloma

Citation
Y. Kanda et al., Lack of correlation between clinical characteristics and serum soluble Fasligand levels in patients with multiple myeloma, LEUK LYMPH, 40(3-4), 2001, pp. 351-356
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
40
Issue
3-4
Year of publication
2001
Pages
351 - 356
Database
ISI
SICI code
1042-8194(200101)40:3-4<351:LOCBCC>2.0.ZU;2-S
Abstract
Multiple myeloma is characterized by the accumulation of malignant plasma c ells in the bone marrow and rarely cured by chemotherapy. Villunger et al. showed that the neoplastic plasma cells express Fas ligand (FasL), which tr ansmits ii signal of apoptosis upon ligation to Fas. and suggested that the FasL suppresses the T-cells activated against malignant cells, resulting i n escape from tumour immunity. We examined serum soluble Fast (sFasL) level s in 35 multiple myeloma patients to evaluate the correlation between sFasL levels and clinical characteristics. The serum sFasL levels were not affec ted hy the disease status, serum monoclonal protein levels, or other progno stic factors. We could not determine whether the expression of FasL is invo lved in the poor clinical course of the disease.