Pathology and prognosis of mucinous gastric carcinoma

Citation
K. Yasuda et al., Pathology and prognosis of mucinous gastric carcinoma, J SURG ONC, 76(4), 2001, pp. 272-277
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
JOURNAL OF SURGICAL ONCOLOGY
ISSN journal
0022-4790 → ACNP
Volume
76
Issue
4
Year of publication
2001
Pages
272 - 277
Database
ISI
SICI code
0022-4790(200104)76:4<272:PAPOMG>2.0.ZU;2-C
Abstract
Background and Objectives: Clinicopathologic characteristics of mucinous ga stric carcinoma (MGC) are unclear, and whether surgical results of MGC are unfavorable is controversial. Pathology and prognosis of patients with MGC were studied using multivariate analysis. Methods: The study included 17 patients with MGC and 614 with nonmucinous g astric carcinoma (NGC). The tumor was defined as MC-C when more than one ha lf of tumor area had mucin pools. Patients were evaluated with regard to ag e, ses, rumor location, size, gross type, depth of wall invasion, lymph nod e metastasis, lymphatic and vascular permeations. stage of disease, and ope rative curability. Results: MGC tumors, when compared with NGC tumors, were featured by the la rge size (9.0 vs. 5.2 cm), grossly infiltrative type (76 vs. 30%), T2 or mo re invasion (100 vs 53%), positive lymph node metastasis (88 vs. 32%), lymp hatic permeation (94 vs. 55%), vascular permeation (47 vs. 25%), and stages III and IV (88 vs. 32%). On a multivariate analysis, mucinous histologic t ype was not an independent prognostic factor. Although 5-year survival rate for all MGC patients was lower than that for all NGC patients, the surviva l rate was not different between the MGC and NGC patients when compared in the same category of tumor size, depth of wall invasion, lymph node metasta sis, and stage. Conclusions: MGC is tare and detested mostly in an advanced stage. Mucinous histologic type itself is not a prognostic significance in patients with g astric carcinoma, and the biologic behavior of MGC is similar to that of or dinary advanced gastric carcinoma. (C) 2001 Wiley-Liss, Inc.