Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans

Citation
Wq. Sheng et al., Expression of COL1A1-PDGFB fusion transcripts in superficial adult fibrosarcoma suggests a close relationship to dermatofibrosarcoma protuberans, J PATHOLOGY, 194(1), 2001, pp. 88-94
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF PATHOLOGY
ISSN journal
0022-3417 → ACNP
Volume
194
Issue
1
Year of publication
2001
Pages
88 - 94
Database
ISI
SICI code
0022-3417(200105)194:1<88:EOCFTI>2.0.ZU;2-L
Abstract
The diagnosis of fibrosarcoma has become relatively rare since the recognit ion and definition of certain adult spindle-cell sarcomas, such as monophas ic synovial sarcoma, malignant peripheral nerve sheath tumour (MPNST), and malignant fibrous histiocytoma (MFH), Although most adult fibrosarcomas occ ur within intra- or inter-muscular fibrous tissues, some originate from sup erficial soft tissues (superficially located adult fibrosarcomas) (SAFs), R ecently, the COL1A1-PDGFB chimeric gene resulting from a reciprocal translo cation, t(17;22), and/or a supernumerary ring chromosome, r(17;22), has bee n identified, not only in conventional dermatofibrosarcoma protuberans (DFS P) but also in areas of DFSP with progression to fibrosarcoma (so-called fi brosarcomatous transformation) (FS-DFSP), Since many SAFs are clinically an d histologically similar to DFSP or FS-DFSP, this study postulated that the two group may be interrelated histogenetically. To test this hypothesis, r everse transcription-polymerase chain reaction (RT-PCR) assay was conducted to determine whether COL1A1-PDGFB fusion transcripts could be detected in sis cases of SAF, using archival formalin-fixed, paraffin-embedded tissues. COL1A1-PDGFB fusion transcripts were detected in four of sis SAFs,,whereas no such fusion transcripts could be amplified in five deep-seated fibrosar comas, eight congenital/infantile fibrosarcomas or 28 other spindle-cell tu mours and tumour-like lesions, These results show that at least some cases of SAF are genetically similar to DFSP and FS-DFSP, suggesting that some SA Fs originate from DFSP or involve similar pathogenetic mechanisms. Copyrigh t (C) 2001 John Wiley & Sons, Ltd.