Risk factors of hepatitis C virus-related liver cirrhosis in young adults:Positive family history of liver disease and transporter associated with antigen processing 2 (TAP2)*0201 allele

Citation
N. Akuta et al., Risk factors of hepatitis C virus-related liver cirrhosis in young adults:Positive family history of liver disease and transporter associated with antigen processing 2 (TAP2)*0201 allele, J MED VIROL, 64(2), 2001, pp. 109-116
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF MEDICAL VIROLOGY
ISSN journal
0146-6615 → ACNP
Volume
64
Issue
2
Year of publication
2001
Pages
109 - 116
Database
ISI
SICI code
0146-6615(200106)64:2<109:RFOHCV>2.0.ZU;2-W
Abstract
The aim of this study was to clinically characterize young patients with he patitis-C-related cirrhosis. We compared 27 patients with liver cirrhosis ( Group LC) who were anti-HCV positive, aged 40 years or less at the time of diagnosis, with 323 consecutive patients with HCV-related chronic hepatitis (Group CH) matched for age and gender. Furthermore, Group LC was divided i nto two arbitrary groups (29-35 years, n = 8 /36-40 years, n = 19), based o n the age of patients at the time of diagnosis of liver cirrhosis. Patients ' characteristics and family history were investigated, and the frequency o f transporter associated with antigen processing 2 (TAP2) was determined. A family history of liver disease was present in 40.7% of Group LC but in 18 .0% of Group CH (P < 0.05). The younger the age of diagnosis of cirrhosis i n Group LC, the higher the frequency of a positive family history (29-35 ye ars, 87.5%; 36-40 years, 21.1%, P < 0.05). The frequency of TAP2*0201 was s ignificantly higher in young adult patients with HCV-related liver cirrhosi s than in HCV carriers with normal ALT (P < 0.05), and tended to be higher than in uninfected normal subjects (P = 0.05). The cumulative survival rare of cirrhosis patients with family history of liver diseases was significan tly lower than that of cirrhosis patients without such history(P < 0.05). O ur findings suggest that a positive family history of liver disease and TAP 2*0201 polymorphism may be risk factors for HCV-related liver cirrhosis in young adults. (C) 2001 Wiley-Liss, Inc.