Two-staged treatment with local resection and percutaneous isolated hepatic chemoperfusion for advanced pancreatic cancer with multiple liver metastases: Report of a case

Citation
Y. Suzuki et al., Two-staged treatment with local resection and percutaneous isolated hepatic chemoperfusion for advanced pancreatic cancer with multiple liver metastases: Report of a case, HEP-GASTRO, 48(38), 2001, pp. 574-577
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
HEPATO-GASTROENTEROLOGY
ISSN journal
0172-6390 → ACNP
Volume
48
Issue
38
Year of publication
2001
Pages
574 - 577
Database
ISI
SICI code
0172-6390(200103/04)48:38<574:TTWLRA>2.0.ZU;2-B
Abstract
There have been disappointingly few effective treatment modalities for mult iple liver metastases from pancreatic cancer. Percutaneous isolated hepatic perfusion, which was developed by us for delivering dose-intensive chemoth erapy to the liver, has a high efficacy in the majority of patients with mu ltiple primary and secondary liver tumors. We herein report the first exper ience of a two-stage treatment with extended local resection and subsequent two percutaneous isolated hepatic perfusions for advanced pancreatic ducta l adenocarcinoma with liver metastases. The second percutaneous isolated he patic per fusion with high-dose cisplatin and mitomycin C demonstrated a di stinct regression of metastatic liver tumors. Although a long-term patient survival was not obtained due to local recurrence, liver metastases have be en well controlled ever since. Given that further studies establish the eff icacy of percutaneous isolated hepatic perfusion also in this field, this m odality would be used as prophylaxis as well as treatment of liver metastas is in patients with advanced pancreatic ductal adenocarcinoma.