Background/Aims: It is controversial as to whether gastroenteric bypass is
helpful for patients with unresectable pancreatic cancer. This study was de
signed to evaluate the effects of gastroenteric bypass on dietary intake an
d the symptoms of gastric outlet obstruction in these patients.
Methodology: We reviewed the cases of 101 patients with unresectable pancre
atic cancer surgically treated at the Kobe University Hospital. The effects
of gastroenteric bypass were examined by comparing the dietary intake and
the symptoms of gastric outlet obstruction on admission, 1 month and 3 mont
hs after the operation.
Results: The analyses of dietary intake and the symptoms indicated that the
gastroenteric bypass operation was not helpful for most of the patients wi
th unresectable pancreatic cancer. Multivariate logistic regression model r
evealed that dietary intake on admission was the strongest parameter for di
etary intake at one month after operation. The patients with a low dietary
intake on admission often required a nasogastric tube after the bypass oper
ation, reflecting progression of the disease.
Conclusions: Gastroenteric bypass had no advantage to improve dietary intak
e and symptoms for almost all the patients with unresectable pancreatic can
cer. It was effective only for patients with a high dietary intake without
symptoms of gastric outlet obstruction on admission.