Clinical prevalence, antimicrobial susceptibility, and geographic resistance patterns of enterococci: Results from the SENTRY Antimicrobial Surveillance Program, 1997-1999

Citation
De. Low et al., Clinical prevalence, antimicrobial susceptibility, and geographic resistance patterns of enterococci: Results from the SENTRY Antimicrobial Surveillance Program, 1997-1999, CLIN INF D, 32, 2001, pp. S133-S145
Citations number
91
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
1058-4838 → ACNP
Volume
32
Year of publication
2001
Supplement
2
Pages
S133 - S145
Database
ISI
SICI code
1058-4838(20010515)32:<S133:CPASAG>2.0.ZU;2-K
Abstract
As part of the SENTRY Antimicrobial Resistance Surveillance Program, a tota l of 4998 strains of enterococci isolated from 1997 to 1999 were processed. The occurrence of enterococcal infections by species and site of infection was analyzed, as were the occurrence of vancomycin-resistant enterococci ( VRE) and their resistance phenotypes and genotypes. Trends in antimicrobial susceptibility to a variety of agents (including experimental compounds) w ere also reported. Enterococci accounted for >9% of isolates from all blood stream infections (BSIs) in North America. Ampicillin was active against st rains from Latin America and Europe but not against those from the United S tates and Canada. US isolates were considerably more resistant to vancomyci n (17% resistant strains in 1999) than were those from patients in the rest of the world. The highest proportion of VRE was observed among BSI isolate s (81.7%). Quinupristin-dalfopristin, chloramphenicol, and doxycycline were the most active agents tested against VRE. The results of this study confi rm the worldwide trend in increasing occurrence of enterococci and the emer ging pattern of antimicrobial resistance among such isolates.