Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3, and 22q13 correlate with postoperative recurrence in breast cancer

Citation
A. Hirano et al., Allelic losses of loci at 3p25.1, 8p22, 13q12, 17p13.3, and 22q13 correlate with postoperative recurrence in breast cancer, CLIN CANC R, 7(4), 2001, pp. 876-882
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
1078-0432 → ACNP
Volume
7
Issue
4
Year of publication
2001
Pages
876 - 882
Database
ISI
SICI code
1078-0432(200104)7:4<876:ALOLA3>2.0.ZU;2-0
Abstract
We previously defined 18 chromosomal regions in which frequent allelic loss es were observed in breast cancers CT. Sate ct at, Cancer Res., 50: 7184-71 89, 1990; Y. Harada et al., Cancer (Phila.), 74: 2281-2286, 1994; I. Ito et ah, Br. J. Cancer, 71: 438-441, 1995; K. Tsukamoto ef al., Cancer (Phila.) , 78: 1929-1934, 1996; S. Matsumoto et at, Genes Chromosomes Cancer, 20: 26 8-274, 1997; T. Yokota er at, Jpn. J. Cancer Res., 88: 959-964, 1997; K. Ts ukamoto et al, Cancer (Phila.), 82: 317-322, 1998; A. Iida et at, Genes Chr omosomes Cancer, 21: 108-112, 1998; K. Fukino ef at, Genes Chromosomes Canc er, 24: 345-350, 1999; T. Yokota et al., Cancer (Phila.), 85: 447-452, 1999 ; Y. Utada et al., Jpn. J. Cancer Res., 91: 293-300, 2000). To identify spe cific allelic losses that might correlate with postoperative recurrence, we examined tumors from a cohort of 504 breast cancer patients, who were foll owed clinically for 5 years postoperatively, for allelic losses of 18 micro satellite markers. Patients whose tumors had lost an allele at 3p25.1, 8p22 , 13q12, 17p13.3, or 22q13 had significantly higher risks of recurrence tha n those whose tumors retained both alleles at those loci; at 3p25.1, the 5- year recurrence rate was 27% among patients with losses versus 18% with ret ention (P = 0.0131); at 8p22, 27% versus 14% (P = 0.0129); at 13q12, 28% ve rsus 15% (P 0.0109); at 17p13.3, 27% versus 20% (P = 0.0382); and at 22q13, 29% versus 20% (P = 0.0477). These data indicate that loss of heterozygosi ty at any one of these five specific loci is a significant predictor of pos toperative recurrence among patients who have undergone surgery for breast cancer. These allelic losses can serve as negative prognostic indicators to guide postoperative management of patients.