Effects of lanthanide ions on hydrolysis of phosphatidylinositol in human erythrocyte membranes

Citation
Hx. Liu et al., Effects of lanthanide ions on hydrolysis of phosphatidylinositol in human erythrocyte membranes, CHIN SCI B, 46(5), 2001, pp. 401-403
Citations number
4
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
1001-6538 → ACNP
Volume
46
Issue
5
Year of publication
2001
Pages
401 - 403
Database
ISI
SICI code
1001-6538(200103)46:5<401:EOLIOH>2.0.ZU;2-2
Abstract
The effects of lanthanides on the hydrolysis of phosphatidylinositol in hum an erythrocyte membranes were studied. H-3-inositol labeling chromatography and HPLC were used to determine inositol 1, 4, 5-triphosphate and diacylgl ycerol separately, the hydrolytic products of phosphatidylinositol due to t he reaction of lanthanide ions with human erythrocyte membranes. The unhydr olyzed phosphatidylinositol in membranes was also determined. The results i ndicate that the hydrolysis of phosphatidylinositol can be promoted by lant hanides (La3+, Ce3+, Y3+, Tb3+) and the effects of La3+ and Ce3+ are strong er than those of Y3+ and Tb3+.