alpha-Synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia

Citation
Y. Kitamura et al., alpha-Synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia, BRAIN RES, 898(1), 2001, pp. 181-185
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
898
Issue
1
Year of publication
2001
Pages
181 - 185
Database
ISI
SICI code
0006-8993(20010413)898:1<181:APINSI>2.0.ZU;2-0
Abstract
alpha -Synuclein, a presynaptic protein, is markedly included in Lewy bodie s (LB) in Parkinson's and LB diseases. In this study, neuronal loss and the activation of glial cells such as microglia and astrocytes: were induced b y neurodegenerative insults such as the injection of kainic acid and occlus ion of the middle cerebral artery. In contrast, immunoreactivity for alpha -synuclein did not change even at 7 days after these insults. These results suggest that alpha -synuclein protein may be so scarcely scavenged by glia l cells that it readily condenses in neurodegenerative regions. (C) 2001 El sevier Science B.V. All rights reserved.