Bioactive four-membered heterocyclic compounds: The anti -> syn interconversion in dithietane-1,3-dioxide

Citation
Jg. Contreras et St. Madariaga, Bioactive four-membered heterocyclic compounds: The anti -> syn interconversion in dithietane-1,3-dioxide, BIOORG CHEM, 29(2), 2001, pp. 57-64
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
BIOORGANIC CHEMISTRY
ISSN journal
0045-2068 → ACNP
Volume
29
Issue
2
Year of publication
2001
Pages
57 - 64
Database
ISI
SICI code
0045-2068(200104)29:2<57:BFHCTA>2.0.ZU;2-0
Abstract
The anti-dithietane-1,3-dioxide --> syn-dithietane-1,3-dioxide isomerizatio n reaction has been theoretically studied on the frame of MO theory both in the gas phase and in solution. in the gas phase the anti (IIa) <----> syn (II) equilibrium is slightly displaced to the anti isomer formation. The sy n concentration ([Syn]) is ca. 36% in the gas phase, whereas in low polarit y solvent. such as carbon tetrachloride, [Syn] is ca. 63%. In medium-high p olarity solvents like acetonitrile and dimethyl-sulfoxide the [ anti]/[ syn ] ratio is Ca. 0.37. (C) 2001 Academic Press.