Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation

Citation
N. Behan et al., Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation, BIOMATERIAL, 22(11), 2001, pp. 1335-1344
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary
Journal title
BIOMATERIALS
ISSN journal
0142-9612 → ACNP
Volume
22
Issue
11
Year of publication
2001
Pages
1335 - 1344
Database
ISI
SICI code
0142-9612(200106)22:11<1335:PNCNAM>2.0.ZU;2-2
Abstract
Poly n-butyl cyanoacrylate has been used in the synthesis of nanoparticles by dispersion polymerisation in aqueous media. Following establishment of a thermometric procedure for assessment of monomer reactivity, the relations hips between monomer-polymer conversion reactions and particle development at various pH values was investigated. Particle size was measured during th e synthesis process using a laser diffraction technique and final particle character was assessed by scanning electron microscopy. Optimum conditions for particle production were a dispersion medium of pH 2.5 at a temperature of 65 degreesC, with dextran 70 used as a steric stabiliser. In the presen ce of dextran, following a period of equilibration, colloidally stable part icles form, but in the absence of dextran particles are colloidally unstabl e and rapidly coalesce. Measurement of molecular weight changes through the synthesis process show an upward shift consistent with the initial formati on of oligomers, which then further polymerise through a re-initiation re-p olymerisation process until an equilibrium molecular weight is reached. (C) 2001 Elsevier Science Ltd. All rights reserved.