Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice

Drebot, MA Gavrilovskaya, I Mackow, ER Chen, ZX Lindsay, R Sanchez, AJ Nichol, ST Artsob, H

Ma. Drebot et al., Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice, VIRUS RES, 75(1), 2001, pp. 75-86

25

INGLESE

Article

Microbiology

VIRUS RESEARCH

0168-1702 → ACNP

75

1

2001

75 - 86

ISI

0168-1702(200105)75:1<75:GASCOS>2.0.ZU;2-N

In Canada, hantavirus infected deer mice (Peromyscus maniculatus) have been collected from British Columbia to Newfoundland. Partial sequencing of G1 and N protein encoding regions from Canadian Peromyscus maniculatus borne h antaviruses demonstrated the existence of significant genotypic divergence among strains. Phylogenetic analysis showed that Sin Nombre (SN)-like virus es from eastern and western Canadian deer mice can be divided into at least two blood-based genogroups. Sequencing of mitochondrial DNA from infected deer mice originating from various eastern and western provinces showed tha t SN-like virus genogroups appeared to be associated with distinct haplotyp es of mice. Sera from deer mice infected with eastern and western viral gen otypes neutralized the Sill Nombre virus strain. Convict Creek 107, but not the New York 1 hantavirus. Despite the genetic heterogeneity of Canadian S N-like strains these hantaviruses do not appear to define unique hantavirus serotypes. (C) 2001 Elsevier Science B.V. All rights reserved.