Sustained and selective attention as measures of genetic liability to schizophrenia

Citation
La. Jones et al., Sustained and selective attention as measures of genetic liability to schizophrenia, SCHIZOPHR R, 48(2-3), 2001, pp. 263-272
Citations number
62
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Psychiatry,"Neurosciences & Behavoir
Journal title
SCHIZOPHRENIA RESEARCH
ISSN journal
0920-9964 → ACNP
Volume
48
Issue
2-3
Year of publication
2001
Pages
263 - 272
Database
ISI
SICI code
0920-9964(20010330)48:2-3<263:SASAAM>2.0.ZU;2-K
Abstract
We tested for a relationship between attention and genetic liability to sch izophrenia. Samples of probands with DSM-IV schizophrenia (n = 20), their w ell first-degree relatives (n = 40) and healthy controls (n = 82) were test ed using measures of sustained attention (degraded-stimulus continuous perf ormance test: DS-CPT) and selective attention (spatial negative priming tas k). Assuming a liability-threshold model, we predicted that probands would display greater attentional decrements than controls and that the relatives would show intermediate levels of decrement. We did not observe the predic ted pattern of effect using either measure, although the probands showed a trend towards less negative priming. However, our results may have been aff ected by self-selection bias in probands and relatives and clinical heterog eneity among probands, which could have reduced our power to detect effects . (C) 2001 Elsevier Science B.V. All rights reserved.