Caloric restriction mimetics: Metabolic interventions

Citation
R. Weindruch et al., Caloric restriction mimetics: Metabolic interventions, J GERONT A, 56, 2001, pp. 20-33
Citations number
162
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public Health & Health Care Science","Medical Research General Topics
Journal title
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
ISSN journal
1079-5006 → ACNP
Volume
56
Year of publication
2001
Pages
20 - 33
Database
ISI
SICI code
1079-5006(200103)56:<20:CRMMI>2.0.ZU;2-Q
Abstract
Caloric restriction (CR) retards diseases and aging in laboratory rodents a nd is now being tested in nonhuman primates. One way to apply these finding s to human health is to identify and test agents that may mimic critical ac tions of CR. Panel 2 focused on two outcomes of CR, reduction of oxidative stress and improved glucoregulation, for which candidate metabolic mimics e xist. It was recommended that studies on oxidative stress should emphasize mitochondrial function and to test the efficacy of nitrone and other antiox idants in mimicking CR's effects. Studies should also focus on the long-ter m effects of compounds known to lower circulating glucose and insulin conce ntrations or to increase insulin sensitivity. Also, four other developing a reas were identified: intermediary metabolism, response to infection, stres s responses, and source of dietary fat. These areas are important because e ither they hold promise for the discovery of new mimetics or they need to b e explored prior to initiation of CR trials in humans. Other recommendation s were that transgenic approaches and adult-onset CR should be emphasized i n future studies.