Can Mycobacterium tuberculosis infection prevent asthma and other allergicdisorders?

Citation
N. Suzuki et al., Can Mycobacterium tuberculosis infection prevent asthma and other allergicdisorders?, INT A AL IM, 124(1-3), 2001, pp. 113-116
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
ISSN journal
1018-2438 → ACNP
Volume
124
Issue
1-3
Year of publication
2001
Pages
113 - 116
Database
ISI
SICI code
1018-2438(200101/03)124:1-3<113:CMTIPA>2.0.ZU;2-S
Abstract
It is generally considered that tuberculosis (TB) is a disease which upregu lates Th1 cell function. There is a hypothesis that infection of Mycobacter ium tuberculosis may prevent allergic disorders such as bronchial asthma. H owever, our clinical experience of patients with TB somewhat conflicts this hypothesis. Hence, we investigated Th1/Th2 balance in the peripheral blood of patients with active TB by measuring serum levels of IgE antibody and b y intracellular cytokine assay. We found that serum levels of IgE in the pa tients with active TB were significantly higher than in those with lung can cer or with COPD. In the TB patients, titers of IgE tended to correlate wit h disease severity. Intracellular cytokine assay demonstrated that IFN-gamm a -positive cells were significantly decreased in the patients with active TB compared to normal controls. The ratio of IFN-gamma -positive (Th1-like) /IL4-positive (Th2-like) cells was remarkably reduced in the TB patients (p < 0.0001). This ratio showed a significant negative correlation with eryth rocyte sedimentation rate and with C-reactive protein. Therapy against TB f or 2-3 months did not result in significant changes of the Th1/Th2 ratio. T hese findings suggest that infection of M. tuberculosis does not systematic ally upregulate Th1 cells in some patients, and is unlikely to prevent alle rgic disorders like asthma. Copyright <(c)> 2001 S. Karger AG,Basel.