Cerebrospinal fluid and serum neuron-specific enolase levels after febrileseizures

Citation
T. Tanabe et al., Cerebrospinal fluid and serum neuron-specific enolase levels after febrileseizures, EPILEPSIA, 42(4), 2001, pp. 504-507
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
EPILEPSIA
ISSN journal
0013-9580 → ACNP
Volume
42
Issue
4
Year of publication
2001
Pages
504 - 507
Database
ISI
SICI code
0013-9580(200104)42:4<504:CFASNE>2.0.ZU;2-Z
Abstract
Purpose: Neuron-specific enolase (NSE) has been established as a reliable m arker of neuronal damage in various neurologic disorders. The aim of this s tudy was to evaluate whether febrile seizures (FS) cause brain damage, base d on the serum and cerebrospinal fluid (CSF) levels of NSE. Methods: Fifty-three patients aged from 6 months to 7 years were enrolled. Among them, 36 patients had generalized seizures, and 17 had partial seizur es. The maximal seizure duration was 90 min. Blood and CSF samples for meas urement of NSE were obtained immediately after the seizure. NSE was measure d using an enzyme immunoassay (EIA). Results; Serum and CSF levels of NSE r anged up to 10 ng/mL, but very high levels were nor observed. In patients w ith partial seizures, the NSE level in the CSF and the ratio of the CSF to serum NSE levels showed a strong correlation with seizure duration. Convers ely, there were no correlations between NSE levels and seizure duration in the patients with generalized seizures. Conclusions: These results indicate that FS seldom cause severe neurologic damage, but prolonged partial seizures may cause slight neuronal injury.