Clinicopathologic analysis of breast carcinoma with chromosomal aneusomy detected by fluorescence in situ hybridization

Citation
F. Tsukamoto et al., Clinicopathologic analysis of breast carcinoma with chromosomal aneusomy detected by fluorescence in situ hybridization, CANC CYTOP, 93(2), 2001, pp. 165-170
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER CYTOPATHOLOGY
ISSN journal
0008-543X → ACNP
Volume
93
Issue
2
Year of publication
2001
Pages
165 - 170
Database
ISI
SICI code
0008-543X(20010425)93:2<165:CAOBCW>2.0.ZU;2-G
Abstract
BACKGROUND. The clinicopathologic characteristics of breast carcinoma with chromosomal aneusomy detected by fluorescence in situ hybridization (FISH) have yet to be clarified. METHODS. Fine-needle aspiration biopsy (FNAB) samples were obtained from 11 3 breast tumors and were subjected to FISH analysis using centromeric probe s for chromosomes 1, 11, and 17 to study a numerical aberration of these ch romosomes and its correlation with various clinicopathologic features of br east tumors. RESULTS. Polysomy was observed in 77.0%, 50.5%, and 37.2% of breast carcino ma samples for chromosomes I, It, and 17, respectively, and monosomy was ob served in 1.8%, 8.8%, and 22.1% for chromosomes 1, 11, and 17, respectively . High histologic grade showed a significant correlation (P < 0.05) with po lysomy of chromosome 11. Lymph node metastasis showed a significant correla tion (P 0.05) with polysomy of all three chromosomes, and positivity of lym ph node metastasis increased as the number of polysomic chromosomes increas ed. In addition, estrogen receptor negativity was correlated significantly (P < 0.05) with monosomy of chromosome 17, and progesterone receptor negati vity was correlated significantly (P < 0.05) with polysomy of chromosomes 1 1 and 17. CONCLUSIONS, Aneusomy of chromosome 1, 11, or 17 detected by FISH is correl ated significantly with various clinicopathologic features of breast carcin oma. Because FISH analysis of chromosomal aneusomy can be done using FNAB s amples, this technique seems to have the potential to be used for a better, preoperative definition of the biologic characteristics of breast tumors. Cancer (Cancer Cytopathol) 2001;93:165-170. (C) 2001 American Cancer Societ y.