INTRODUCTION. Peripheral T-cell lymphoma (PTCL) accounts for 10-20% of all
non-Hodgkin lymphomas in the United States. In this study, the authors revi
ewed the cytologic and immunophenotypic findings of 33 fine-needle aspirati
ons (FNAs) of PTCL.
METHODS. Thirty-three FNAs from 26 patients (12 females and 14 males) with
PTCL were identified during 1991-1999. The patients' age ranged from 19 to
96 years. Immunophenotyping was performed in 24 cases by using either flow
cytometry (FC; 21 cases) or immunocytochemistry (IC; 3 cases). Follow-up in
cluded review of prior or current histology and clinical records.
RESULTS. Nine cases were associated with mycosis fungoides, three cases wer
e classified as T-cell chronic lymphocytic leukemia, and two were angioimmu
noblastic adenopathy (AILD)-like T-cell lymphoma. The remaining 19 were cla
ssified as PTCL, not otherwise specified. The latter consisted of eight mix
ed cell variant, eight large cell variant, and three anaplastic variant. On
e of the mixed cell variant and one of the large cell Variants contained nu
merous epithelioid histiocytes (Lennert lymphoma). Thirty (91%) cases had a
definitive diagnosis of malignant lymphoma. Twenty-two cases (2 IC and 20
FC) showed a predominant population of T lymphocytes without a monoclonal B
-cell population. In addition, FC revealed an aberrant expression of T-cell
markers in 13 cases. Two cases were interpreted as "atypical lymphoid popu
lation"; one case was an AILD-like T-cell lymphoma, and the other case was
PTCL, large eel type. One case initially was interpreted as granulomatous l
ymphadenitis; subsequent biopsy revealed PTCL, Lennert type.
CONCLUSIONS. Peripheral T-cell lymphoma is a heterogeneous group of lesions
with diverse cytomorphology. Cytologic analysis and immunophenotyping is a
n accurate method of diagnosing peripheral T-cell lymphoma. Cancer (Cancer
Cytopathol) 2001;93:151-159. (C) 2001 American Cancer Society.