Fine-needle aspiration biopsy of peripheral T-cell lymphomas - A cytologicand immunophenotypic study of 33 cases

Citation
Jl. Yao et al., Fine-needle aspiration biopsy of peripheral T-cell lymphomas - A cytologicand immunophenotypic study of 33 cases, CANC CYTOP, 93(2), 2001, pp. 151-159
Citations number
60
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER CYTOPATHOLOGY
ISSN journal
0008-543X → ACNP
Volume
93
Issue
2
Year of publication
2001
Pages
151 - 159
Database
ISI
SICI code
0008-543X(20010425)93:2<151:FABOPT>2.0.ZU;2-R
Abstract
INTRODUCTION. Peripheral T-cell lymphoma (PTCL) accounts for 10-20% of all non-Hodgkin lymphomas in the United States. In this study, the authors revi ewed the cytologic and immunophenotypic findings of 33 fine-needle aspirati ons (FNAs) of PTCL. METHODS. Thirty-three FNAs from 26 patients (12 females and 14 males) with PTCL were identified during 1991-1999. The patients' age ranged from 19 to 96 years. Immunophenotyping was performed in 24 cases by using either flow cytometry (FC; 21 cases) or immunocytochemistry (IC; 3 cases). Follow-up in cluded review of prior or current histology and clinical records. RESULTS. Nine cases were associated with mycosis fungoides, three cases wer e classified as T-cell chronic lymphocytic leukemia, and two were angioimmu noblastic adenopathy (AILD)-like T-cell lymphoma. The remaining 19 were cla ssified as PTCL, not otherwise specified. The latter consisted of eight mix ed cell variant, eight large cell variant, and three anaplastic variant. On e of the mixed cell variant and one of the large cell Variants contained nu merous epithelioid histiocytes (Lennert lymphoma). Thirty (91%) cases had a definitive diagnosis of malignant lymphoma. Twenty-two cases (2 IC and 20 FC) showed a predominant population of T lymphocytes without a monoclonal B -cell population. In addition, FC revealed an aberrant expression of T-cell markers in 13 cases. Two cases were interpreted as "atypical lymphoid popu lation"; one case was an AILD-like T-cell lymphoma, and the other case was PTCL, large eel type. One case initially was interpreted as granulomatous l ymphadenitis; subsequent biopsy revealed PTCL, Lennert type. CONCLUSIONS. Peripheral T-cell lymphoma is a heterogeneous group of lesions with diverse cytomorphology. Cytologic analysis and immunophenotyping is a n accurate method of diagnosing peripheral T-cell lymphoma. Cancer (Cancer Cytopathol) 2001;93:151-159. (C) 2001 American Cancer Society.