A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions

Citation
Pj. Westenend et al., A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesions, CANC CYTOP, 93(2), 2001, pp. 146-150
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER CYTOPATHOLOGY
ISSN journal
0008-543X → ACNP
Volume
93
Issue
2
Year of publication
2001
Pages
146 - 150
Database
ISI
SICI code
0008-543X(20010425)93:2<146:ACOACA>2.0.ZU;2-C
Abstract
BACKGROUND. Several arguments are used for choosing either fine-needle aspi ration cytology (FNAC) or core needle biopsy (CNB) in the evaluation of bre ast lesions. Comparison of published data on both methods is complicated by differences in study design, calculations, and operator experience. The ob jective of this study was to make a direct comparison of both methods. METHODS. In 286 breast lesions (cysts and microcalcifications without a sof t tissue mass excluded), both ultrasound-guided FNAC and CNB were performed in the same session by the same operator. Histologic follow-up was collect ed, and for those lesions that were not excised the results of the most rec ent mammography was used. A combination of the findings of both FNAC and CN B were evaluated. RESULTS. Core needle biopsy and FNAC do equally well for sensitivity (88% v s. 92%), positive predictive value for malignancy (99% vs. 100%), and inade quate rate (7% vs. 7%). However, statistical differences are found for the specificity (CNB, 90%; FNAC, 82%). In addition, differences are found in th e positive predictive value of both suspicious (CNB, 100%; FNAC, 78%) and a typia (CNB, 80%; FNAC, 18%) and for the suspicious rare (CNB, 5%; FNAC, 13% ) reflecting difficulties in interpreting some FNACs. Combining the finding s of both FNAC and CNB results in an increase in absolute sensitivity, a de crease in the positive predictive value of atypia compared with FNAC and CN B per se, and a decrease in the inadequate rate for cancers. CONCLUSIONS. For the lesions selected in this study, FNAC and CNB are compa rable for most parameters, but CNB has a higher specificity and lower suspi cious rate. Combining results of FNAC and CNB leads to an increase in absol ute sensitivity without affecting specificity and a decrease in the inadequ ate rate for cancers. Cancer (Cancer Cytopathol) 2001;93:146-150, (C) 2001 American Cancer Society.