New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, andtheir potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice

Citation
I. Kimura et al., New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, andtheir potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice, BIOORG MED, 11(8), 2001, pp. 985-989
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
8
Year of publication
2001
Pages
985 - 989
Database
ISI
SICI code
0960-894X(20010423)11:8<985:NTMAAM>2.0.ZU;2-8
Abstract
Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or Commi phora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect on exudative pouch fluid, angiogenesis, and granuloma weights in adjuvant-ind uced air-pouch granuloma of mice. Its effects were more marked than those o f hydrocortisone and the 50% aqueous methanolic extract of the crude drug. Myrrhanol A is a plausible candidate for a potent anti-inflammatory agent. (C) 2001 Elsevier Science Ltd. All rights reserved.