Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases

Citation
Ch. Rickert et al., Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases, AM J PATH, 158(4), 2001, pp. 1525-1532
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
AMERICAN JOURNAL OF PATHOLOGY
ISSN journal
0002-9440 → ACNP
Volume
158
Issue
4
Year of publication
2001
Pages
1525 - 1532
Database
ISI
SICI code
0002-9440(200104)158:4<1525:PHASCI>2.0.ZU;2-T
Abstract
We studied 23 pediatric high-grade astrocytomas by comparative genomic hybr idization. Chromosomal imbalances were found in 10 of 10 anaplastic astrocy tomas and 11 of 13 glioblastomas and consisted of +1q(43%), +3q(26%), +1p, +2q, +5q (22%), -22q (34%), -6q, -10q (30%), -9q, -11q, -13q, -16q, and -17 p (22%). Anaplastic astrocytomas frequently showed +5q (40%), +1q (30%), -2 2q (50%), -6q, -9q (40%), and -12q (30%); glioblastomas +1q (54%), +3q (38% ), +2q, +17q (23%), -6q, -8q, -10q, -13q, and -17p (31%). Minimal common re gions mapped to +1q21-41, +3q27-qter, +2q31-32, +5q14-22, -22q12-qter, -10q 23-25, -6q25-qter, -9q34.2, -11q14-22, -16q22-qter, and -17p. High-level ga ins were located on 10 (7 cases), 2q, 7q (4 cases), 3q (3 cases), 9, 17q (2 eases), 4q, 8q, 18, and 20q (1 case). A significantly shorter survival was found for anaplastic astrocytomas showing +1q CP < 0.05), MIB-1 proliferat ion index >25% (P < 0.001) and glioblastomas (P < 0.05). Compared with adul t cases, +1p, +2q, and +21q as well as -6q, -11q, and -16q were more freque nt in pediatric malignant astrocytomas. Among the Latter +5q, -6q, -9q, -12 q, and -22q were characteristic for pediatric anaplastic astrocytomas and 1q, +3q, +16p, -8q, and -17p for pediatric glioblastomas. Our results show that chromosomal aberrations differ between pediatric anaplastic astrocytom as and glioblastomas as well as between pediatric and adult high-grade astr ocytomas, supporting the notion of a different genetic pathway. Furthermore , gains of chromosomal material on Iq might be correlated with a worse prog nosis in pediatric anaplastic astrocytomas.