Intraarterial infusion chemotherapy and radiotherapy with of without surgery for patients with locally advanced or recurrent breast cancer

Citation
M. Murakami et al., Intraarterial infusion chemotherapy and radiotherapy with of without surgery for patients with locally advanced or recurrent breast cancer, AM J CL ONC, 24(2), 2001, pp. 185-191
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
ISSN journal
0277-3732 → ACNP
Volume
24
Issue
2
Year of publication
2001
Pages
185 - 191
Database
ISI
SICI code
0277-3732(200104)24:2<185:IICARW>2.0.ZU;2-4
Abstract
We analyzed response, side effects, and local control rates of a multimodal treatment consisting of intraaterial infusion chemotherapy (IAIC) and radi otherapy with or without surgery for patients with locally advanced or recu rred breast cancer. Thirty-three patients, clinically diagnosed as stage II B in 1, ILIA in 2, IIIB in 12, IV in 18, were treated from 1991 to 1998. Tw enty-five were primary and eight were recurrent cases after surgery. IAIC s tarted as initial treatment up to three times maximum. In most cases, doxor ubicin 50 mg, cisplatin 50 mg, and mitomycin 10 mg were infused in the subc lavian and/or internal mammary artery. After IAIC, patients in primary case s underwent radical mastectomy or breast conservation surgery, after radiot herapy at a total dose of 50 Gy/25 fractions/5 weeks with a boost of 10 Gy. In recurrent cases, a full dose of radiotherapy was delivered. Clinical ob jective and complete response rates were 78% and 9% after IAIC. Despite a h igh rate of residual positive margin (67%) or clinically residual carcinoma , local recurrence developed only in 2 patients (6%) and local control rate s at 5 years were calculated as 89%. Bone marrow suppression was frequent, and skin vesiculation (15%) and ulceration (9%) were experienced after IAIC . Skin ulcer (6%), brachial plexus neuropathy (3%), and radiation pneumonit is (3%) occurred as late toxicity. IAIC was effective as an induction treat ment and radiotherapy played a role of local control for patients with loca lly advanced or recurrent breast cancer.