Severe fenitrothion poisoning complicated by rhabdomyolysis in psychiatricpatient

Citation
K. Futagami et al., Severe fenitrothion poisoning complicated by rhabdomyolysis in psychiatricpatient, ACT MED OKA, 55(2), 2001, pp. 129-132
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
ACTA MEDICA OKAYAMA
ISSN journal
0386-300X → ACNP
Volume
55
Issue
2
Year of publication
2001
Pages
129 - 132
Database
ISI
SICI code
0386-300X(200104)55:2<129:SFPCBR>2.0.ZU;2-3
Abstract
Non-traumatic rhabdomyolysis associated with organophosphate intoxication h as not been generally reported. We report here in a severe case of fenitrot hion poisoning complicated by rhabdomyolysis. A 43-year-old woman ingested approximately 100 ml of fenitrothion emulsion (50%) in an attempt to commit suicide. On day 3 after admission, her creatine phosphokinase (CPK) peaked at 47,762IU/L. She received supportive treatment included sodium bicarbona te and fluid resuscitation, However, muscarinic symptoms including excessiv e miosis and salivation developed on day 5 when her CPK levels decreased. T he delay in cholinergic symptoms might have been due to the trihexyphenidyl she took with the antipsychotic drugs. Fortunately, the present patient re covered from the acute cholinergic crisis, and acute renal failure was prev ented by early diagnosis. This is a case of organophosphate poisoning compl icated by rhabdomyolysis in a psychiatric patient. The masking of acute cho linergic symptoms should be taken into consideration in such patients.