Impact of repeat hepatectomy on recurrent colorectal liver metastases

Citation
S. Suzuki et al., Impact of repeat hepatectomy on recurrent colorectal liver metastases, SURGERY, 129(4), 2001, pp. 421-428
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
SURGERY
ISSN journal
0039-6060 → ACNP
Volume
129
Issue
4
Year of publication
2001
Pages
421 - 428
Database
ISI
SICI code
0039-6060(200104)129:4<421:IORHOR>2.0.ZU;2-I
Abstract
Background. Hepatic recurrence is seen in approximately 40% of patients und ergoing hepatectomy for colorectal metastases. This study was designed to a ssess the risks and clinical benefits of repeat hepatectomy for those patie nts. Methods. Twenty-six patients underwent repeat hepatectomy for hepatic recur rence, and their clinical data were retrospectively reviewed for operative morbidity and mortality performance level, and survival. Results. There was no operative mortality after repeat hepatectomy. Operati ve bleeding was significantly Increased in the second hepatectomy; but oper ating time, duration of hospital stay, and performance status after the sec ond hepatectomy were comparable with those of the initial hepatectomy. The median survival time from the second hepatectomy was 31 months, and the 3- and 5-year survival rates were 62 % and 32 %, respectively. A short disease -free interval (6 months or less) between the initial hepatectomy and diagn osis of hepatic recurrence in the remnant liver was significantly associate d with poor survival after the second hepatectomy. Conclusions. Repeat resection contributed to clinical benefits for selected patients with hepatic recurrence after the initial hepatectomy for colorec tal liver metastases. However appearance of hepatic recurrence within 6 mon ths or less after the initial hepatectomy is a poor prognostic factor for r epeat hepatectomy.