Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma

Citation
S. Takeno et al., Immunohistochemical study of leukocyte infiltration and expression of hsp70 in esophageal squamous cell carcinoma, ONCOL REP, 8(3), 2001, pp. 585-590
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
3
Year of publication
2001
Pages
585 - 590
Database
ISI
SICI code
1021-335X(200105/06)8:3<585:ISOLIA>2.0.ZU;2-R
Abstract
It is reported that macrophages and CD4(+) or CD8(+) cytotoxic T cells have an important role in the suppression of cancer progression. The aim of thi s study was to clarify these immune responses in patients with esophageal c ancer. We enrolled 28 patients with pT2 esophageal cancer that had been res ected without preoperative adjuvant therapy. The correlations between the n umbers of infiltrating CD4(+), CD8(+) and CD68(+) cells, the expression of heat shock protein 70 (hsp70) and a variety of clinicopathologic factors we re analyzed. The numbers of CD8(+) T cells and CD68(+) macrophages showed a significant positive correlation with tumor diameter (p = 0.01, p = 0.037) and the expression of hsp70 (p = 0.01, p = 0.02) and a negative correlatio n with lymph node metastasis (p = 0.0079, p < 0.0001). The expression of hs p70 exhibited a negative correlation with lymph node metastasis (p = 0.023) . CD8(+) T cells and CD68(+) macrophages might have a suppressive function against esophageal cancer progression. Our results suggested that hsp70 mig ht play an important role in the presentation of tumor specific antigens.