Blood pressure in diabetic nephropathy - current controversies

Citation
E. Ritz et al., Blood pressure in diabetic nephropathy - current controversies, J INTERN M, 249(3), 2001, pp. 215-223
Citations number
76
Language
INGLESE
art.tipo
Review
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
JOURNAL OF INTERNAL MEDICINE
ISSN journal
0954-6820 → ACNP
Volume
249
Issue
3
Year of publication
2001
Pages
215 - 223
Database
ISI
SICI code
0954-6820(200103)249:3<215:BPIDN->2.0.ZU;2-K
Abstract
Hypertension has been recognized as an early and constant feature of diabet ic nephropathy. but recent studies also suggest that a genetic predispositi on to hypertension is an important risk factor for diabetic nephropathy. An tihypertensive treatment attenuates progression in diabetic nephropathy, bu t there is increasing evidence that very early treatment and very low targe t blood pressures should be implemented. There is also evidence for local a ctivation of the renin system in the kidney as a result of hyperglycaemia. Apart from blood pressure. proteinuria should be monitored and dosing of AC E inhibitors should be guided. also by reduction of protein excretion.