Fc gamma RIII b and Fc gamma RIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy
S. Taniuchi et al., Fc gamma RIII b and Fc gamma RIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy, HUMAN IMMUN, 62(4), 2001, pp. 408-413
We studied 18 children with autoimmune neutropenia (AIN) to evaluate whethe
r the re was a possible relationship between the specificity of granulocyte
autoantibodies (anti-NA1.2) and the phenotype of the NA system. Direct gra
nulocyte immunofluorescence test (D-GIFT) was positive in all patients, and
indirect granulocyte immunofluorescence test (I-GIFT) was positive in 17 o
f these 18 patients, respectively. Fourteen of 18 patients showed preferent
ial binding to neutrophils from NA(1+2-) phenotyped donors. Immunoblotting
with anti-Fc gamma RIIImAb showed that IgG prepared from 7 of 12 patients p
recipitated both Fc gamma RIIIb from NA1 and NA2 neutrophil lysate, whereas
the other 5 precipitated only NA1. Patients' IgG did not react with purifi
ed Fc gamma RIIa. Fc gamma RIIIb genotype were NA(1+2-) in 15 of 18 patient
s and NA(1+2+) in the other 3,. Fc gamma RIIa type of all patients were (HR-). These distributions were significantly different from those of healthy
Japanese blood donors (n = 608). The genotype of Fc gamma RIIIb and Fc gam
ma RIIa may affect the production of neutrophil specific auto-antibodies in
AIN of infancy and influence its clinical course. (C) American Society for
Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science
Inc.