Fc gamma RIII b and Fc gamma RIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy

Citation
S. Taniuchi et al., Fc gamma RIII b and Fc gamma RIIa polymorphism may affect the production of specific NA1 autoantibody and clinical course of autoimmune neutropenia of infancy, HUMAN IMMUN, 62(4), 2001, pp. 408-413
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
HUMAN IMMUNOLOGY
ISSN journal
0198-8859 → ACNP
Volume
62
Issue
4
Year of publication
2001
Pages
408 - 413
Database
ISI
SICI code
0198-8859(200104)62:4<408:FGRBAF>2.0.ZU;2-1
Abstract
We studied 18 children with autoimmune neutropenia (AIN) to evaluate whethe r the re was a possible relationship between the specificity of granulocyte autoantibodies (anti-NA1.2) and the phenotype of the NA system. Direct gra nulocyte immunofluorescence test (D-GIFT) was positive in all patients, and indirect granulocyte immunofluorescence test (I-GIFT) was positive in 17 o f these 18 patients, respectively. Fourteen of 18 patients showed preferent ial binding to neutrophils from NA(1+2-) phenotyped donors. Immunoblotting with anti-Fc gamma RIIImAb showed that IgG prepared from 7 of 12 patients p recipitated both Fc gamma RIIIb from NA1 and NA2 neutrophil lysate, whereas the other 5 precipitated only NA1. Patients' IgG did not react with purifi ed Fc gamma RIIa. Fc gamma RIIIb genotype were NA(1+2-) in 15 of 18 patient s and NA(1+2+) in the other 3,. Fc gamma RIIa type of all patients were (HR-). These distributions were significantly different from those of healthy Japanese blood donors (n = 608). The genotype of Fc gamma RIIIb and Fc gam ma RIIa may affect the production of neutrophil specific auto-antibodies in AIN of infancy and influence its clinical course. (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.