An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese

Citation
Bcy. Wong et al., An evaluation of invasive and non-invasive tests for the diagnosis of Helicobacter pylori infection in Chinese, ALIM PHARM, 15(4), 2001, pp. 505-511
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
4
Year of publication
2001
Pages
505 - 511
Database
ISI
SICI code
0269-2813(200104)15:4<505:AEOIAN>2.0.ZU;2-H
Abstract
Background: Different tests are available for diagnosing Helicobacter pylor i infection. Aim: To compare the most commonly used tests either alone or in combination in Chinese patients with respect to routine clinical use or research purpo se. Methods: A total of 294 consecutive dyspeptic patients without previous H. pylori treatment were recruited. During upper endoscopy, biopsies were take n from the antrum and corpus, for a commercially available CLO-test, an in- house rapid urease test, culture, polymerase chain reaction and histologica l examination. Patients then received a C-13-urea breath test. The H. pylor i status of each patient was determined by a concordance of test results. Results: For routine clinical use, histology (antral plus corpus biopsies) had an accuracy of 100%,, whilst the rapid urease test had an accuracy of 9 9.7%. The C-13-urea breath test was equally reliable, with an accuracy of 9 4.5%. Combinations of two tests did not confer additional advantage over th e most accurate single test. For research purposes, the accuracy of using t he criteria of two positives out of three diagnostic tests was 100%, and eq uivocal results were not found. Conclusion: Histology with or without a rapid urease test was highly accura te for routine clinical use. Alternatively, the C-13-urea breath test was a n equally reliable non-invasive test. The two positives out of three tests approach was highly reliable in predicting H. pylori status of untreated Ch inese patients in a research setting.