Review article: food hypersensitivity and irritable bowel syndrome

Citation
S. Zar et al., Review article: food hypersensitivity and irritable bowel syndrome, ALIM PHARM, 15(4), 2001, pp. 439-449
Citations number
115
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
4
Year of publication
2001
Pages
439 - 449
Database
ISI
SICI code
0269-2813(200104)15:4<439:RAFHAI>2.0.ZU;2-R
Abstract
Irritable bowel syndrome is a common condition but its pathophysiology rema ins poorly understood. Many irritable bowel syndrome patients give a histor y of food intolerance, but data from dietary elimination and re-challenge s tudies are inconclusive. Multiple aetiopathological mechanisms have been po stulated. The gut has an extensive immune system but current understanding of process ing of food antigens in health and disease is limited. There is no clinical ly useful marker available to test for food hypersensitivity in irritable b owel syndrome. Researchers have employed both skin tests and serum immunogl obulins (IgG and IgE) as markers of food hypersensitivity in various disord ers including irritable bowel syndrome, but published data are equivocal. In this article, the evidence for the role of food hypersensitivity in irri table bowel syndrome is reviewed and, based on the available data, a possib le pathophysiological hypothesis has been formulated.