Review article: iron and inflammatory bowel disease.

Citation
B. Oldenburg et al., Review article: iron and inflammatory bowel disease., ALIM PHARM, 15(4), 2001, pp. 429-438
Citations number
97
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
4
Year of publication
2001
Pages
429 - 438
Database
ISI
SICI code
0269-2813(200104)15:4<429:RAIAIB>2.0.ZU;2-O
Abstract
Both anaemia of iron deficiency and anaemia of chronic disease are frequent ly encountered in inflammatory bowel disease. Anaemia of iron deficiency is mostly due to inadequate intake or loss of iron. Anaemia of chronic diseas e probably results from decreased erythropoiesis, secondary to increased le vels of proinflammatory cytokines, reactive oxygen metabolites and nitric o xide. Assessment of the iron status in a condition associated with inflammation, such as inflammatory bowel disease, is difficult. The combination of serum transferrin receptor with ferritin concentrations, however, allows a reliab le assessment of the iron deficit. The best treatment for anaemia of chronic disease is the cure of the underl ying disease. Erythropoietin reportedly may increase haemoglobin levels in some of these patients. The anaemia of iron deficiency is usually treated w ith oral iron supplements. Iron supplementation may lead to an increased in flammatory activity through the generation of reactive oxygen species. To d ate, data from studies in animal models of inflammatory bowel disease suppo rt the theoretical disadvantage of iron supplementation in this respect. Th e results, however, cannot easily be extrapolated to the human situation, b ecause the amount of supplemented iron in these experiments was much higher than the dose used in patients with iron deficiency.