Allele frequency of HLA-B39 in the Japanese population and identification of a novel B39 allele, B*3923

Citation
T. Akesaka et al., Allele frequency of HLA-B39 in the Japanese population and identification of a novel B39 allele, B*3923, TISSUE ANTI, 57(2), 2001, pp. 169-172
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
0001-2815 → ACNP
Volume
57
Issue
2
Year of publication
2001
Pages
169 - 172
Database
ISI
SICI code
0001-2815(200102)57:2<169:AFOHIT>2.0.ZU;2-1
Abstract
A new HLA-B39 allele, B*3923, was found in the Japanese population. Compare d with B*39022, the new allele had a single point mutation at position 503 in exon 3 with an amino acid substitution, Gln144Arg. To determine B39 alle le frequency in Japanese, 275 B39-positive samples from 3277 Japanese indiv iduals were examined by polymerase chain reaction using microtitre plate hy dribization (PCR-MPH) and single-strand conformation polymorphism (PCR-SSCP ). The frequency of B*3923 was estimated to be 0.4% in B39 alleles of the J apanese population. B*3923 was found in samples from four Japanese individu als, all of whom have DRB1*1406.