Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma

Citation
M. Kawashima et al., Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma, MOD PATHOL, 14(3), 2001, pp. 197-201
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Journal title
MODERN PATHOLOGY
ISSN journal
0893-3952 → ACNP
Volume
14
Issue
3
Year of publication
2001
Pages
197 - 201
Database
ISI
SICI code
0893-3952(200103)14:3<197:PDS(IM>2.0.ZU;2-F
Abstract
The level of prostaglandin D synthase (PGDS), a major protein constituent o f cerebrospinal fluid (CSF), is altered in various brain diseases, includin g meningitis. However, its role in the brain remains unclear. PGDS is mainl y synthesized in the arachnoid cells, the choroid plexus and oligodendrocyt es in the central nervous system. Among brain tumors, meningiomas showed in tense immunoreactivity to RODS in the perinuclear region. Thus, PGDS has be en considered a specific cell. marker of meningioma. In this study, we exam ined 25 meningeal hemangiopericytomas (HPCs) and found that 16 of the tumor s (64%) showed immunoreactivity for PGDS in the perinuclear region, For com parison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined. Meningiomas showed positive immunoreactivity for PGDS in 13 cases (80%), Ex cept for one case located at the sacrum, none of the other soft-tissue HPCs showed immunostaining for PODS, Mesenchymal chondrosarcoma arises in the b ones of the skull, and its histological. pattern resembles that of HPC; how ever, it showed no immunoreactivity for RODS. Neither choroid plexus papill omas nor oligodendrogliomas were immunopositive for PGDS. These findings su ggest that meningeal HPCs may have a unique molecular phenotype that is dis tinct from that of the soft-tissue HPCs, The origin of meningeal HPCs may b e more closely related to the arachnoid cells.