Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice

Citation
T. Murase et al., Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice, J LIPID RES, 42(3), 2001, pp. 372-378
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF LIPID RESEARCH
ISSN journal
0022-2275 → ACNP
Volume
42
Issue
3
Year of publication
2001
Pages
372 - 378
Database
ISI
SICI code
0022-2275(200103)42:3<372:DDSHFA>2.0.ZU;2-C
Abstract
Diacylglycerol (DG) comprises up to approximately 10% of various edible oil s, In the present study, we examined the effects of dietary DC consisting m ainly of 1,3-species on body weight, body fat accumulation, and mRNA levels of various genes involved in energy homeostasis in obesity-prone C57BL/6J mice. Five-month feeding with the high triacylglycerol (TG) diet (30% TG 13% sucrose) resulted in significant increases in body weight, visceral fat accumulation, and circulating insulin and leptin levels compared with mice fed the control diet (5% TC), Compared with mice fed the high TG diet, bod y weight gain and visceral fat weight were reduced by 70% and 79%, respecti vely, in those fed the high DG diet (30% DG + 13% sucrose), In addition, ci rculating leptin and insulin levels were reduced to the respective control levels, Compared with high TG feeding, high DG feeding suppressed the eleva tion of leptin mRNA expression in adipose tissue, and upregulated acyl-coen zyme (Co)A oxidase and acyl-CoA synthase mRNA expression in the liver. Thes e results indicate that dietary DG is beneficial for suppression of high fa t diet-induced body fat accumulation, Furthermore, it is suggested that str uctural differences in DG and TG, but not the composition of fatty acid, ma rkedly affect nutritional behavior of lipids.