Chronic diversion of bile to the urinary bladder induces pancreatic growthin dogs

Citation
M. Takahashi et al., Chronic diversion of bile to the urinary bladder induces pancreatic growthin dogs, J GASTRO S, 4(5), 2000, pp. 513-519
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN journal
1091-255X → ACNP
Volume
4
Issue
5
Year of publication
2000
Pages
513 - 519
Database
ISI
SICI code
1091-255X(200009/10)4:5<513:CDOBTT>2.0.ZU;2-G
Abstract
The aim of this study was to elucidate the mechanism of chronic biliary div ersion and its effect on pancreatic growth. In the first part of the study nine mongrel dogs underwent diversion of bile from the gastrointestinal tra ct by ligating the common bile duct and interposing a segment of jejunum be tween the :nary bladder (cholecystojejunocystostomy [CJC]). Despite the los s of 7% of their gallbladder and the un body weight at 12 weeks after bilio enteric diversion, CJC dogs had significantly greater pancreatic wet weight than control dogs (51.2 +/- 2.7 g vs. 37.1 +/- 2.2 g). In the second part of the study, sis other dogs underwent CJC. Twelve weeks later, bilioenteri c continuity was restored bq creating a cholecystojejunoduodenostomy (CJD). The dogs a;ere given butter (3 g/kg) by mouth (prior to surgery, 12 weeks after CJC, and 4 weeks after CJD). Pancreatic excisional biopsy specimens w ere obtained at each operation and at autopsy. CJC induced more pancreatic RNA per milligram of weight (743 +/- 52, CJC; 579 +/- 44, prior to surgery, P < 0.05 vs. CJC; 520 +/- 26 <mu>g/100 mg tissue, CJD, P < 0.01 vs. CJC), but not more DNA, and significantly higher basal plasma cholecystokinin lev els and butter-stimulated cholecystokinin responses when compared with valu es prior to surgery or following CJD. We conclude that chronic biliary dive rsion induces pancreatic growth associated with hypersecretion of cholecyst okinin in dogs.