Prostate-specific antigen: Current status

Citation
M. Lukes et al., Prostate-specific antigen: Current status, FOL BIOL, 47(2), 2001, pp. 41-49
Citations number
68
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Experimental Biology
Journal title
FOLIA BIOLOGICA
ISSN journal
0015-5500 → ACNP
Volume
47
Issue
2
Year of publication
2001
Pages
41 - 49
Database
ISI
SICI code
0015-5500(2001)47:2<41:PACS>2.0.ZU;2-I
Abstract
PSA is the most important of all tumor markers because it has significant a pplications in all aspects of the management of men with prostatic disease. Certainly, the most important utilization of PSA is for early detection of this most ubiquitous of all human neoplasms. In this article the authors describe the molecular forms of PSA and their c haracteristics, the factors influencing values of serum concentration of PS A, the problems of screening, and particularly the possibility to use PSA f or detection of prostate carcinoma. A big problem in prostate carcinoma det ection is the low specificity of PSA at the concentrations between 4-10 ng/ ml, the so-called diagnostic gray zone, where the incidence of prostate car cinoma is only 25%, The authors evaluate the methods which make it possible to increase the sensitivity and/or specificity of PSA detection, such as P SA density, PSA density of the transition zone, PSA velocity, PSA doubling time, age-specific PSA, free PSA and, prospectively, the use of the RT-PCR technique.