Significance of histiocytes in cervical smears from peri/postmenopausal women

Citation
R. Tambouret et al., Significance of histiocytes in cervical smears from peri/postmenopausal women, DIAGN CYTOP, 24(4), 2001, pp. 271-275
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
DIAGNOSTIC CYTOPATHOLOGY
ISSN journal
8755-1039 → ACNP
Volume
24
Issue
4
Year of publication
2001
Pages
271 - 275
Database
ISI
SICI code
8755-1039(200104)24:4<271:SOHICS>2.0.ZU;2-6
Abstract
Histiocytes in cervicovaginal smears from peri- or postmenopausal women hav e been viewed as a potential indicator of endometrial neoplasia, but recent studies have refuted that view. This study further defines the clinical si gnificance of such findings. All cervical smears were selected from women ( greater than or equal to 50 yr) in whom the presence of histiocytes was men tioned; pertinent clinical history, follow-up information, and selected sli des were reviewed. Among 105,225 total cervicovaginal smears from a 3.5-yr period, 106 smears from 103 women were identified. Forty-two patients (41%) were on hormone replacement therapy (2 on tamoxifen), and 23 (22.3%) patie nts experienced vaginal bleeding, all of whom had biopsy or cytology follow -up. Ten (9.6%) patients had no follow-up, 35 (32%) had repeat smears only, and 58 (56.3%) had endometrial/endocervical sampling. In 28 patients, the index smear was categorized as other than within normal limits or benign ce llular changes; of these, 24 had subsequent tissue sampling and 4 had cytol ogy follow-up. Of the patients with tissue sampling, 51 (84%) had benign fi ndings (including polyps), 2 (3.5%) had hyperplasia, and 5 (10%) had adenoc arcinoma. All 5 patients with adenocarcinoma had endometrial glandular cell s on the smear, and 4 had vaginal bleeding. One patient with hyperplasia ha d vaginal bleeding, and the other was on tamoxifen and had endometrial glan dular cells on the smear. None of the patients having only histiocytes on t heir smears and no clinical symptoms or risk factors had endometrial adenoc arcinoma or hyperplasia. These findings support the conclusion that the pre sence of histiocytes alone on cervicovaginal smears from peri- or postmenop ausal women is nonspecific and of no major clinical significance in the abs ence of other clinical or cytologic findings. (C) 2001 Wiley-Liss, Inc.