Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions

Citation
Be. Vogel et Em. Hedgecock, Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions, DEVELOPMENT, 128(6), 2001, pp. 883-894
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
DEVELOPMENT
ISSN journal
0950-1991 → ACNP
Volume
128
Issue
6
Year of publication
2001
Pages
883 - 894
Database
ISI
SICI code
0950-1991(200103)128:6<883:HACEMO>2.0.ZU;2-1
Abstract
him-4 mutations cause a novel syndrome of tissue fragility, defective cell migration and chromosome instability in Caenorhabditis elegans. Null mutant s have abnormal escape reflex, mispositioning of the vas deferens and uteru s, and mitotic chromosome loss and multinucleate cells in the germline, The him-4 gene product, hemicentin, is a conserved extracellular matrix protei n with 48 tandem immunoglobulin repeats flanked by novel terminal domains. Secreted from skeletal muscle and gonadal leader cells, hemicentin assemble s into fine tracks at specific sites, where it contracts broad regions of c ell contact into oriented linear junctions. Some tracks organize hemidesmos omes in the overlying epidermis, Hemicentin tracks facilitate mechanosensor y neuron anchorage to the epidermis, gliding of the developing gonad along epithelial basement membranes and germline cellularization.