Jm. Borras et al., Compliance, satisfaction, and quality of life of patients with colorectal cancer receiving home chemotherapy or outpatient treatment: a randomised controlled trial, BR MED J, 322(7290), 2001, pp. 826-828A
General & Internal Medicine","Medical Research General Topics
Objective To compare chemotherapy given at home with outpatient treatment i
n terms of colorectal cancer patients' safety, compliance: use of health se
rvices, quality of life, and satisfaction with treatment.
Design Randomised controlled trial.
Setting Large teaching hospital.
Participants 87 patients receiving adjuvant or palliative chemotherapy for
Interventions Treatment with fluorouracil (with or without folinic acid or
levamisole) at outpatient clinic or at home.
Main outcome measures Treatment toxicity patients' compliance with treatmen
t, quality of life, satisfaction with care, and use of health resources.
Results 49 patients were treated at outpatient clinic and 45 at home. The t
wo groups were balanced in terms of age, ses, site of cancer, and disease s
tage. Treatment related toxicity was similar in the two groups (difference
7%, (95% confidence interval - 12% to 26%), but there were more voluntary:
withdrawals from treatment in the outpatient group than in the home group (
14% v 2%: difference 12% (1% to 24%)). There were no differences between gr
oups in terms of quality of life scores during and after treatment. Levels
of patient satisfaction were higher in the home treatment group, specifical
ly with regard to information received and nursing care. There were no sign
ificant differences in use of health services.
Conclusions Home chemotherapy seemed an acceptable and safe alternative to
hospital treatment for patients with colorectal cancer that mall improve co
mpliance and satisfaction with treatment.