Effect of tamsulosin hydrochloride on sympathetic hyperactivity in amyotrophic lateral sclerosis

Citation
T. Ohno et al., Effect of tamsulosin hydrochloride on sympathetic hyperactivity in amyotrophic lateral sclerosis, AUTON NEURO, 88(1-2), 2001, pp. 94-98
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
ISSN journal
1566-0702 → ACNP
Volume
88
Issue
1-2
Year of publication
2001
Pages
94 - 98
Database
ISI
SICI code
1566-0702(20010412)88:1-2<94:EOTHOS>2.0.ZU;2-D
Abstract
We assessed subclinical sympathetic hyperactivity in amyotrophic lateral sc lerosis (ALS) patients, which might be followed by an autonomic spell leadi ng to circulatory collapse, or sudden death as the disease progresses, and investigated the effect of tamsulosin hydrochloride (TSHC) on sympathetic h yperactivity. We measured the plasma norepinephrine (NE) concentrations of 41 ALS patients and 10 normal controls. TSHC, a selective alpha 1 blocker, was then administered to 10 ALS patients who had high plasma NE and to the 10 normal controls. Subsequent plasma NE change was evaluated for the possi ble alleviating effect of TSHC on subclinical sympathetic hyperactivity in ALS. Plasma NE was high in 20 of the ALS patients (48.8%), but had no relat ion to respiratory problems, which supports the previous speculation that p lasma NE increases in ALS are not secondary to respiratory deficit, but ref lect the primary pathomechanism of the disease. ALS patients showed a marke d decrease in the NE concentration after TSHC administration, whereas there was no change in the controls. In conclusion. TSHC may be useful for suppr essing central sympathetic hyperactivity. presumably the primary pathomecha nism in ALS, and for preventing autonomic spells during the advanced stage of the disease. (C) 2001 Elsevier Science B.V. All rights reserved.